(R,R)-DACH-Phenyl Trost Ligand

(1R,2R)-N1,N2-Bis(2-diphenylphosphinobenzylidene)cyclohexane-1,2-diamine
CAS Number
138517-61-0
PubChem
Molecular Formula
C42H44N2O2
Molecular Weight
612.81 g/mol
Chiral Ligands Catalysts
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(R,R)-DACH-phenyl Trost ligand is the privileged chiral diphosphine ligand developed by Barry Trost, built on a trans-1,2-diaminocyclohexane (DACH) backbone with diphenylphosphinoaryl substituents. It is a benchmark ligand for palladium-catalyzed asymmetric allylic alkylation (AAA), enabling construction of complex chiral centers with high enantiopurity.

Applications

  • Palladium-catalyzed allylic alkylation (Tsuji-Trost)
  • Enantioselective allylic amination
  • Asymmetric allylic substitution in API synthesis
  • Construction of all-carbon quaternary stereocenters

Specifications

Property Value
CAS 138517-61-0
Molecular Formula C42H44N2O2
Molecular Weight 612.81 g/mol
Purity ≥99%
Appearance Yellow crystalline solid

Features

  • Privileged Trost ligand family
  • Excellent for Pd-AAA reactions
  • Modular DACH-derived scaffold
  • Industrial-grade purity available

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