(S)-MonoPhos
(S)-(-)-3,3'-Dimethyl-2-diphenylphosphino-1,1'-binaphthyl-2'-yl dimethylphosphoramidite
Chiral Ligands
Catalysts
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(S)-MonoPhos is a chiral monodentate phosphoramidite ligand developed by Feringa and de Vries. Derived from (S)-BINOL, it forms highly enantioselective rhodium complexes for asymmetric hydrogenation of dehydroamino acids and enamides with low catalyst loadings.
Applications
- Asymmetric hydrogenation of dehydroamino acids (Rh)
- Enantioselective hydrogenation of enamides
- Asymmetric hydrogenation of itaconic acid derivatives
- Pharmaceutical synthesis of α-amino acids
Specifications
| Property | Value |
|---|---|
| CAS | 376355-59-8 |
| Molecular Formula | C23H22NO3P |
| Molecular Weight | 391.40 g/mol |
| Purity | >99% |
| Appearance | White to off-white solid |
Features
- Cost-effective monodentate design
- Low Rh loadings (S/C up to 10,000)
- High-throughput catalyst screening platform
- Compatible with BINOL-derived libraries
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Chiral Ligands
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Chiral Ligands
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Chiral Ligands
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Chiral Ligands
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Chiral Ligands
Catalysts
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Chiral Ligands
(R)-BINAP
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MW:
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Chiral Ligands
Catalysts
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Chiral Ligands
(R)-BINOL
(R)-(+)-1,1'-Bi-2-naphthol
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Formula:
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MW:
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Chiral Ligands
Catalysts
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Chiral Ligands
(R)-CHIRAPHOS
(2R,3R)-Bis(diphenylphosphino)butane
CAS:
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Formula:
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MW:
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Chiral Ligands
Catalysts
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