(S)-PROPHOS

(S)-(-)-1,2-Bis(diphenylphosphino)propane
CAS Number
71497-67-9
PubChem
Molecular Formula
C25H24P2
Molecular Weight
386.4 g/mol
Chiral Ligands Catalysts
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(S)-PROPHOS is a chiral bidentate phosphine ligand featuring a methyl-substituted stereocenter on the propane backbone. It is widely used in rhodium-catalyzed asymmetric hydrogenation and hydroformylation reactions.

Applications

  • Asymmetric hydrogenation of enamides (Rh)
  • Enantioselective hydroformylation
  • Asymmetric allylic alkylation (Pd)
  • Synthesis of chiral α-amino acid derivatives

Specifications

Property Value
CAS 71497-67-9
Molecular Formula C25H24P2
Molecular Weight 386.40 g/mol
Purity >99%
Optical Rotation [α]D -18° (c 1, CHCl3)

Features

  • Compact chiral backbone
  • Excellent for Rh-catalyzed hydrogenation
  • Cost-effective chiral diphosphine
  • Good air stability

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