(S)-SEGPHOS
(S)-5,5'-Bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole
Chiral Ligands
Catalysts
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(S)-SEGPHOS is a chiral diphosphine ligand developed by Takasago, characterized by its narrow bite angle due to the bi-1,3-benzodioxole backbone. It delivers superior enantioselectivity in ruthenium-catalyzed hydrogenation of carbonyl and olefin substrates.
Applications
- Asymmetric hydrogenation of ketones (Ru-SEGPHOS)
- Enantioselective hydrogenation of β-keto esters
- Asymmetric Heck reactions (Pd)
- Pharmaceutical synthesis of chiral alcohols
Specifications
| Property | Value |
|---|---|
| CAS | 866081-54-1 |
| Molecular Formula | C38H28O4P2 |
| Molecular Weight | 622.62 g/mol |
| Purity | >99% |
| Appearance | White to off-white solid |
Features
- Narrow bite angle enhances enantioselectivity
- Superior to BINAP in many hydrogenations
- Wide substrate scope
- Commercial production scale
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Chiral Ligands
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Chiral Ligands
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Chiral Ligands
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Chiral Ligands
(R)-BINAP
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Chiral Ligands
Catalysts
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Chiral Ligands
(R)-BINOL
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Chiral Ligands
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Chiral Ligands
(R)-CHIRAPHOS
(2R,3R)-Bis(diphenylphosphino)butane
CAS:
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MW:
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Chiral Ligands
Catalysts
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