(S)-SPINOL

(S)-(-)-1,1'-Spirobiindane-7,7'-diol
CAS Number
144013-93-2
PubChem
Molecular Formula
C21H14O2
Molecular Weight
298.34 g/mol
Chiral Ligands Catalysts
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(S)-SPINOL ((S)-1,1’-spirobiindane-7,7’-diol) is the privileged chiral spirocyclic diol developed by Zhou Qi-Lin. It serves as the core scaffold for SDP diphosphines, SIPHOS phosphoramidites, and numerous other privileged ligands that dominate modern asymmetric hydrogenation.

Applications

  • Precursor to SDP diphosphine ligands
  • Precursor to SIPHOS phosphoramidites
  • Asymmetric hydrogenation (Rh, Ru complexes)
  • Enantioselective cross-coupling reactions

Specifications

Property Value
CAS 144013-93-2
Molecular Formula C21H14O2
Molecular Weight 298.34 g/mol
Purity >99%
Optical Rotation [α]D -160° (c 1, CHCl3)

Features

  • Privileged spirocyclic scaffold
  • Rigid C2-symmetric backbone
  • Modular derivatization to SDP, SIPHOS
  • Industrial-scale production available

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