(S)-t-Bu-BOX
(S)-2,2'-Isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]
Chiral Ligands
Catalysts
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(S)-t-Bu-BOX is a chiral C2-symmetric bisoxazoline (BOX) ligand featuring tert-butyl substituents that create a sterically demanding chiral pocket. It forms highly enantioselective complexes with copper, zinc, magnesium, and other Lewis acids.
Applications
- Asymmetric Diels-Alder reactions (Cu)
- Enantioselective Henry reactions (Cu)
- Asymmetric Mukaiyama aldol reactions (Cu)
- Asymmetric cyclopropanation (Cu)
Specifications
| Property | Value |
|---|---|
| CAS | 200938-56-4 |
| Molecular Formula | C14H24N2O2 |
| Molecular Weight | 252.35 g/mol |
| Purity | >99% |
| Optical Rotation | [α]D -120° (c 1, CHCl3) |
Features
- C2-symmetric bisoxazoline scaffold
- Sterically demanding tert-butyl groups
- Versatile across Lewis acid metals
- High enantioselectivity in cycloadditions
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