RuPhos
2-Dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl
Catalyst Ligands
Catalysts
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RuPhos (2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1’-biphenyl) is a Buchwald biaryl phosphine ligand optimized for C–N cross-coupling. It excels at coupling sterically hindered primary amines with aryl chlorides and bromides, a frequent challenge in pharmaceutical synthesis.
Applications
- Buchwald-Hartwig amination of hindered amines
- Coupling of primary amines with aryl chlorides
- Synthesis of complex aniline derivatives
- Pharmaceutical API manufacturing
Specifications
| Property | Value |
|---|---|
| CAS | 787618-22-8 |
| Molecular Formula | C25H35O2P |
| Molecular Weight | 414.51 g/mol |
| Purity | >99% |
| Appearance | White to off-white crystalline powder |
Features
- Optimized for hindered amine coupling
- Suppresses bis-arylation side products
- Compatible with aryl chlorides
- Industrial API synthesis validated
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Catalyst Ligands
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Catalyst Ligands
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Formula:
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Catalyst Ligands
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Catalyst Ligands
XPhos
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CAS:
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Formula:
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Catalyst Ligands
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Chiral Ligands
(1R,2R)-trans-1,2-Diaminocyclohexane
(1R,2R)-Cyclohexane-1,2-diamine
CAS:
20439-47-8
Formula:
C6H16N2
MW:
116.2 g/mol
Chiral Ligands
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Chiral Ligands
(1S,2S)-trans-1,2-Diaminocyclohexane
(1S,2S)-Cyclohexane-1,2-diamine
CAS:
21439-79-0
Formula:
C6H16N2
MW:
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