SPhos
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
Catalyst Ligands
Catalysts
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SPhos (2-dicyclohexylphosphino-2’,6’-dimethoxybiphenyl) is the iconic Buchwald biaryl phosphine ligand. Its electron-rich and sterically demanding character enables high-yielding Suzuki-Miyaura coupling of sterically hindered aryl chlorides and boronic acids under mild conditions.
Applications
- Suzuki-Miyaura coupling of aryl chlorides (Pd/SPhos)
- Cross-coupling of sterically hindered substrates
- C–N and C–O bond formation (Buchwald-Hartwig)
- Pharmaceutical intermediate synthesis
Specifications
| Property | Value |
|---|---|
| CAS | 657408-07-6 |
| Molecular Formula | C24H25O2P |
| Molecular Weight | 376.43 g/mol |
| Purity | >99% |
| Appearance | White crystalline powder |
Features
- Industry-standard biaryl phosphine
- Activates aryl chlorides at low Pd loadings
- Excellent for hindered biaryl synthesis
- Air-stable, easy to handle
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