XPhos
2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl
Catalyst Ligands
Catalysts
Request Quote
XPhos (2-dicyclohexylphosphino-2’,4’,6’-triisopropylbiphenyl) is a privileged Buchwald biaryl phosphine ligand. The bulky, electron-rich character enables highly efficient Buchwald-Hartwig amination, Suzuki-Miyaura coupling, and other challenging C–C and C–heteroatom bond formations.
Applications
- Buchwald-Hartwig amination (Pd/XPhos)
- Suzuki-Miyaura coupling of aryl chlorides
- C–O and C–S bond formation
- Pharmaceutical API manufacturing
Specifications
| Property | Value |
|---|---|
| CAS | 564483-18-7 |
| Molecular Formula | C24H35P |
| Molecular Weight | 354.50 g/mol |
| Purity | >99% |
| Appearance | White crystalline powder |
Features
- Highly electron-rich biaryl phosphine
- Excellent for C–N coupling reactions
- Low Pd loadings (down to 0.01 mol%)
- Industry-standard for API synthesis
Related Products
Catalyst Ligands
Biphephos
2,2'-Bis[(2,4-di-tert-butylphenoxy)phosphanyloxy]-3,3'-di-tert-butyl-5,5'-dimethoxy-1,1'-biphenyl
CAS:
7604-35-5
Formula:
C29H46O8P2
MW:
584.61 g/mol
Catalyst Ligands
Catalysts
View Details ->
Catalyst Ligands
RuPhos
2-Dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl
CAS:
787618-22-8
Formula:
C25H35O2P
MW:
414.51 g/mol
Catalyst Ligands
Catalysts
View Details ->
Catalyst Ligands
SPhos
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
CAS:
657408-07-6
Formula:
C24H25O2P
MW:
376.43 g/mol
Catalyst Ligands
Catalysts
View Details ->
Catalyst Ligands
Xantphos
4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene
CAS:
161265-03-8
Formula:
C39H32OP2
MW:
578.62 g/mol
Catalyst Ligands
Catalysts
View Details ->
Chiral Ligands
(1R,2R)-trans-1,2-Diaminocyclohexane
(1R,2R)-Cyclohexane-1,2-diamine
CAS:
20439-47-8
Formula:
C6H16N2
MW:
116.2 g/mol
Chiral Ligands
Catalysts
View Details ->
Chiral Ligands
(1S,2S)-trans-1,2-Diaminocyclohexane
(1S,2S)-Cyclohexane-1,2-diamine
CAS:
21439-79-0
Formula:
C6H16N2
MW:
116.2 g/mol
Chiral Ligands
Catalysts
View Details ->