Xantphos

4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene
CAS Number
161265-03-8
PubChem
Molecular Formula
C39H32OP2
Molecular Weight
578.62 g/mol
Catalyst Ligands Catalysts
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Xantphos (4,5-bis(diphenylphosphino)-9,9-dimethylxanthene) is the privileged wide bite-angle (≈108°) bidentate phosphine ligand developed by van Leeuwen. It is the industry standard for rhodium-catalyzed hydroformylation of terminal olefins and is also widely used in palladium-catalyzed cross-coupling reactions.

Applications

  • Rhodium-catalyzed hydroformylation of olefins
  • Palladium-catalyzed Suzuki-Miyaura coupling
  • Buchwald-Hartwig amination (Pd)
  • Hydrocyanation and allylic alkylation

Specifications

Property Value
CAS 161265-03-8
Molecular Formula C39H32OP2
Molecular Weight 578.62 g/mol
Purity >99%
Appearance White to off-white crystalline powder

Features

  • Wide natural bite angle (~108°)
  • Industry standard for linear-selective hydroformylation
  • Robust Pd cross-coupling performance
  • Commercial multiton-scale production

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RuPhos

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SPhos

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Catalyst Ligands

XPhos

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MW: 354.5 g/mol
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Chiral Ligands

(1R,2R)-trans-1,2-Diaminocyclohexane

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CAS: 20439-47-8
Formula: C6H16N2
MW: 116.2 g/mol
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Chiral Ligands

(1S,2S)-trans-1,2-Diaminocyclohexane

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CAS: 21439-79-0
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MW: 116.2 g/mol
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