Grubbs 2nd Generation Catalyst

[1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium(II)
CAS Number
246047-72-3
PubChem
Molecular Formula
C46H65Cl2N2PRu
Molecular Weight
848.97 g/mol
Catalysts Catalyst Precursors
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Grubbs 2nd generation catalyst is the iconic ruthenium-NHC complex developed by Robert Grubbs for olefin metathesis. It offers superior activity, thermal stability, and functional group tolerance compared to the first-generation catalyst, enabling ring-closing metathesis (RCM), cross metathesis (CM), and ring-opening metathesis polymerization (ROMP).

Applications

  • Ring-closing metathesis (RCM) of dienes
  • Cross metathesis (CM) of terminal olefins
  • Ring-opening metathesis polymerization (ROMP)
  • Synthesis of macrocycles and pharmaceuticals

Specifications

Property Value
CAS 246047-72-3
Molecular Formula C46H65Cl2N2PRu
Molecular Weight 848.97 g/mol
Purity >97%
Appearance Brownish-gray crystalline powder

Features

  • Robust across diverse metathesis substrates
  • Tolerates water, air, and functional groups
  • Higher activity than 1st-gen Grubbs
  • Recognized with 2005 Nobel Prize (Grubbs)

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