(R)-2-Methyl-CBS-oxazaborolidine

(4R)-3,4-Dimethyl-2-phenyl-1,3,2-oxazaborolidine
CAS Number
112022-83-0
PubChem
Molecular Formula
C10H14BNO
Molecular Weight
175.04 g/mol
Chiral Catalysts Catalysts
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(R)-2-Methyl-CBS-oxazaborolidine is the enantiomeric Corey-Bakshi-Shibata catalyst, providing access to (S)-configured secondary alcohols from prochiral ketones. It is widely deployed in pharmaceutical process chemistry.

Applications

  • Enantioselective reduction of prochiral ketones
  • Synthesis of (S)-chiral alcohols
  • Reduction of halo-ketones
  • Drug substance manufacturing

Specifications

Property Value
CAS 112022-83-0
Molecular Formula C10H14BNO
Molecular Weight 175.04 g/mol
Purity >97%
Concentration 1.0 M in toluene (typical)

Features

  • Inverse enantioselectivity to S-form
  • High chemical yields
  • Compatible with borane-dimethyl sulfide complex
  • Scales well to multi-kilogram production

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