Hoveyda-Grubbs 2nd Generation Catalyst

[1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(o-isopropoxyphenylmethylene)ruthenium(II)
CAS Number
301224-40-8
PubChem
Molecular Formula
C31H38Cl2N2ORu
Molecular Weight
626.61 g/mol
Catalysts Catalyst Precursors
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Hoveyda-Grubbs 2nd generation catalyst is a chelated ruthenium-NHC complex developed by Hoveyda. Its “boomerang” mechanism allows catalyst recovery and recycling, making it ideal for large-scale and pharmaceutical metathesis applications where residual ruthenium must be minimized.

Applications

  • Ring-closing metathesis (RCM)
  • Cross metathesis (CM) and enyne metathesis
  • Asymmetric metathesis (with chiral variants)
  • Pharmaceutical manufacturing with low Ru residue

Specifications

Property Value
CAS 301224-40-8
Molecular Formula C31H38Cl2N2ORu
Molecular Weight 626.61 g/mol
Purity >97%
Appearance Green crystalline powder

Features

  • Boomerang mechanism enables catalyst recovery
  • Low residual ruthenium in products
  • Excellent air and thermal stability
  • Suitable for cGMP manufacturing

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