IPr·HCl

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride
CAS Number
250249-75-3
PubChem
Molecular Formula
C27H33ClN2
Molecular Weight
425.01 g/mol
Catalyst Precursors Catalysts
Request Quote

IPr·HCl (1,3-bis(2,6-diisopropylphenyl)imidazolium chloride) is the most widely deployed NHC precatalyst in modern transition-metal catalysis. The sterically demanding IPr carbene enables challenging Suzuki-Miyaura, Buchwald-Hartwig, and α-arylation reactions with low catalyst loadings.

Applications

  • Suzuki-Miyaura coupling of aryl chlorides (Pd/IPr)
  • Buchwald-Hartwig amination
  • α-Arylation of carbonyl compounds
  • Nickel-catalyzed cross-electrophile coupling

Specifications

Property Value
CAS 250249-75-3
Molecular Formula C27H33ClN2
Molecular Weight 425.01 g/mol
Purity >99%
Appearance White to off-white solid

Features

  • Industry-standard NHC precatalyst
  • Activates sterically hindered aryl chlorides
  • Compatible with low Pd loadings
  • Air-stable and easy to handle

Related Products

Catalysts

Grubbs 2nd Generation Catalyst

[1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium(II)
CAS: 246047-72-3
Formula: C46H65Cl2N2PRu
MW: 848.97 g/mol
Catalysts Catalyst Precursors
View Details ->
Catalysts

Hoveyda-Grubbs 2nd Generation Catalyst

[1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(o-isopropoxyphenylmethylene)ruthenium(II)
CAS: 301224-40-8
Formula: C31H38Cl2N2ORu
MW: 626.61 g/mol
Catalysts Catalyst Precursors
View Details ->
Catalyst Precursors

IMes·HCl

1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride
CAS: 141556-45-8
Formula: C21H25ClN2
MW: 340.89 g/mol
Catalyst Precursors Catalysts
View Details ->
Chiral Ligands

(1R,2R)-trans-1,2-Diaminocyclohexane

(1R,2R)-Cyclohexane-1,2-diamine
CAS: 20439-47-8
Formula: C6H16N2
MW: 116.2 g/mol
Chiral Ligands Catalysts
View Details ->
Chiral Ligands

(1S,2S)-trans-1,2-Diaminocyclohexane

(1S,2S)-Cyclohexane-1,2-diamine
CAS: 21439-79-0
Formula: C6H16N2
MW: 116.2 g/mol
Chiral Ligands Catalysts
View Details ->
Chiral Ligands

(R,R)-DACH-Phenyl Trost Ligand

(1R,2R)-N1,N2-Bis(2-diphenylphosphinobenzylidene)cyclohexane-1,2-diamine
CAS: 138517-61-0
Formula: C42H44N2O2
MW: 612.81 g/mol
Chiral Ligands Catalysts
View Details ->