(R)-MacMillan Imidazolidinone Catalyst

(2R,5R)-5-Benzyl-2-tert-butyl-3-methylimidazolidin-4-one
CAS Number
187455-14-9
PubChem
Molecular Formula
C13H23NO
Molecular Weight
209.33 g/mol
Chiral Catalysts Catalysts
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(R)-MacMillan imidazolidinone catalyst is the enantiomeric organocatalyst that provides complementary enantioselectivity in iminium ion activation. It is widely used in Diels-Alder and Friedel-Crafts reactions requiring (R)-configured products.

Applications

  • Asymmetric Diels-Alder reactions
  • Enantioselective Friedel-Crafts alkylations
  • Asymmetric conjugate additions
  • Synthesis of (R)-configured carbocycles

Specifications

Property Value
CAS 187455-14-9
Molecular Formula C13H23NO
Molecular Weight 209.33 g/mol
Purity >98%
Appearance White to off-white solid

Features

  • Mirror-image enantioselectivity to (S)-form
  • Robust iminium activation
  • Compatible with Brønsted acid co-catalysts
  • Scalable to multi-gram syntheses

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