(R)-Jørgensen-Hayashi Catalyst

(R)-2-(Diphenyl(trimethylsilyloxy)methyl)pyrrolidine
CAS Number
1185498-19-0
PubChem
Molecular Formula
C20H27NOSi
Molecular Weight
325.52 g/mol
Chiral Catalysts Catalysts
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(R)-Jørgensen-Hayashi catalyst is the enantiomeric diphenylprolinol trimethylsilyl ether organocatalyst. It provides access to opposite enantiomers in iminium and enamine activation pathways compared to the S-form.

Applications

  • Asymmetric Michael additions
  • α-Functionalization of aldehydes and ketones
  • Enantioselective Diels-Alder reactions
  • Organocascade reactions

Specifications

Property Value
CAS 1185498-19-0
Molecular Formula C20H27NOSi
Molecular Weight 325.52 g/mol
Purity >98%
Appearance Colorless to pale yellow oil

Features

  • Mirror-image enantioselectivity to S-form
  • High chemical yields
  • Compatible with brine and aqueous conditions
  • Long shelf-life when properly stored

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