(R)-BINAL-H

Lithium (R)-2,2'-dihydroxy-1,1'-binaphthyl-aluminum hydride complex
CAS Number
100646-12-2
PubChem
Molecular Formula
C30H28AlLiO2
Molecular Weight
454.47 g/mol
Chiral Catalysts Catalysts
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(R)-BINAL-H is the enantiomeric chiral reducing agent of (S)-BINAL-H, prepared from (R)-BINOL. It provides access to opposite enantiomers in the asymmetric reduction of aromatic and α,β-unsaturated ketones.

Applications

  • Asymmetric reduction of aromatic ketones
  • Enantioselective 1,2-reduction of enones
  • Synthesis of (S)-allylic alcohols
  • Pharmaceutical intermediate production

Specifications

Property Value
CAS 100646-12-2
Molecular Formula C30H28AlLiO2
Molecular Weight 454.47 g/mol
Purity >95% (in situ preparation)
Form Solution in THF/toluene

Features

  • Mirror-image enantioselectivity to (S)-BINAL-H
  • High selectivity for 1,2-reduction
  • Predictable stereochemical model
  • Compatible with low-temperature conditions

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