[(R,R)-TsDPEN]Ru(p-cymene)Cl₂

Dichloro[(R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine](p-cymene)ruthenium(II)
CAS Number
192139-92-7
PubChem
Molecular Formula
C31H34Cl2N2O2RuS
Molecular Weight
683.65 g/mol
Chiral Catalysts Catalysts
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[(R,R)-TsDPEN]Ru(p-cymene)Cl₂ is the enantiomeric Noyori-Ikariya catalyst for asymmetric transfer hydrogenation. It produces (R)-configured chiral alcohols and amines from the corresponding prochiral ketones and imines using iPrOH or HCO₂H/Et₃N as hydrogen source.

Applications

  • Asymmetric transfer hydrogenation of ketones
  • ATH of imines to (R)-amines
  • Pharmaceutical synthesis of (R)-drug intermediates
  • Continuous flow ATH processes

Specifications

Property Value
CAS 192139-92-7
Molecular Formula C31H34Cl2N2O2RuS
Molecular Weight 683.65 g/mol
Purity >98%
Appearance Orange crystalline solid

Features

  • Mirror-image enantioselectivity to (S,S)-form
  • No high-pressure H₂ equipment needed
  • Compatible with green solvents (iPrOH, water)
  • Validated for cGMP manufacturing

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