[(S)-DIOP]RhCl Dimer

Dichlorobis[(S)-4,5-bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane]dirhodium
CAS Number
67881-36-7
PubChem
Molecular Formula
C46H48Cl2O4P4Rh2
Molecular Weight
1033.5 g/mol
Chiral Catalysts Catalysts
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[(S)-DIOP]RhCl dimer is the chiral rhodium complex of DIOP, the first practical chiral bidentate phosphine ligand developed by Kagan. It catalyzes asymmetric hydrogenation of prochiral olefins with good enantioselectivity and serves as a foundational catalyst in asymmetric hydrogenation.

Applications

  • Asymmetric hydrogenation of dehydroamino acids
  • Enantioselective hydrogenation of enamides
  • Reduction of α-acetamidocinnamic acid derivatives
  • Synthesis of chiral α-amino acids

Specifications

Property Value
CAS 67881-36-7
Molecular Formula C46H48Cl2O4P4Rh2
Molecular Weight 1033.50 g/mol
Purity >98%
Appearance Orange crystalline solid

Features

  • Historical significance as first practical ligand
  • Excellent for dehydroamino acid substrates
  • Air-stable dimeric complex
  • Activated in situ by hydrogen

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