(S)-TRIP BINOL Phosphoric Acid

(S)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate
CAS Number
1190300-26-9
PubChem
Molecular Formula
C50H49O4P
Molecular Weight
744.89 g/mol
Chiral Catalysts Catalysts
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(S)-TRIP is the most widely used chiral phosphoric acid catalyst developed by List and Akiyama, enabling highly enantioselective transformations of imines, indoles, and other nucleophilic substrates through chiral protonation.

Applications

  • Asymmetric transfer hydrogenation of imines (Hantzsch ester)
  • Enantioselective Friedel-Crafts alkylation
  • Pictet-Spengler reactions
  • Multicomponent reactions (Biginelli, Mannich)

Specifications

Property Value
CAS 1190300-26-9
Molecular Formula C50H49O4P
Molecular Weight 744.89 g/mol
Purity >99%
Appearance White to off-white solid

Features

  • Broad substrate scope
  • Mild metal-free conditions
  • Predictable stereochemical model
  • Robust performance in complex molecule synthesis

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