[(S,S)-TsDPEN]Ru(p-cymene)Cl₂

Dichloro[(S,S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine](p-cymene)ruthenium(II)
CAS Number
192139-90-5
PubChem
Molecular Formula
C31H34Cl2N2O2RuS
Molecular Weight
683.65 g/mol
Chiral Catalysts Catalysts
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[(S,S)-TsDPEN]Ru(p-cymene)Cl₂ is the iconic Noyori-Ikariya catalyst that pioneered asymmetric transfer hydrogenation (ATH). Using isopropanol or azeotropic formic acid/triethylamine as the hydrogen donor, this air-stable ruthenium complex delivers outstanding enantioselectivity for ketone and imine reduction under mild conditions.

Applications

  • Asymmetric transfer hydrogenation of aromatic ketones
  • ATH of imines to chiral amines
  • Reduction of α,β-unsaturated carbonyls
  • Pharmaceutical manufacturing (sertraline, aprepitant intermediates)

Specifications

Property Value
CAS 192139-90-5
Molecular Formula C31H34Cl2N2O2RuS
Molecular Weight 683.65 g/mol
Purity >98%
Appearance Orange crystalline solid

Features

  • Operationally simple ATH protocol
  • No high-pressure hydrogen required
  • Air-stable pre-catalyst
  • Industrial-scale validated

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