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rhodium asymmetric hydrogenation enamide dehydroamino acid DIPAMP BINAPINE SEGPHOS chiral ruthenium BINAP diamine aryl ketone DPEN DAIPEN Noyori asymmetric transfer hydrogenation TsDPEN ketone reduction palladium asymmetric cross-coupling Suzuki Heck atroposelective ketone CBS oxazaborolidine borane Corey copper conjugate addition 1,4-addition quaternary center phosphoramidite BOX chiral phosphoric acid TRIP BINOL organocatalysis Brønsted acid titanium TADDOL Lewis acid Diels-Alder carbonyl-ene cyanation metathesis Grubbs Hoveyda-Grubbs ring-closing cross-metathesis manganese Mn-salen Jacobsen base metal epoxidation pincer Buchwald biaryl phosphine SPhos XPhos RuPhos iridium unfunctionalized olefin MonoPhos Crabtree NHC IMes IPr carbene Trost DACH allylic alkylation API nickel Negishi spiro SPINOL SIPHOS Zhou Qi-Lin rigid backbone iron cobalt sustainable hydroformylation Xantphos Biphephos oxo process industrial C-H activation directing group olefin hydroboration hydrosilylation MacMillan imidazolidinone SOMO photoredox dual catalysis radical visible light cinchona alkaloid phase-transfer cinchonidine quinine Jorgensen Hayashi diarylprolinol enamine iminium BINAL-H chiral hydride reduction bisoxazoline cycloaddition t-Bu-BOX DIOP hydrogenation bisphosphine CHIRAPHOS PROPHOS evolution allylic substitution green chemistry flow chemistry ionic liquids proline DMAP sustainability process catalysis custom synthesis CDMO manufacturing

Ketone

2 articles

Taxonomy

BINAP–Ruthenium Catalyzed Asymmetric Hydrogenation: Noyori's Foundational Platform

The combination of (BINAP)RuCl₂ with a chiral 1,2-diamine co-ligand, recognized by the 2001 Nobel Prize awarded to Ryoji Noyori, established the modern field of asymmetric …

2026-06-10
Methodology, Science 6 tags
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Taxonomy

BINAL-H: Noyori's Chiral Hydride Reagent for Enantioselective Reduction

BINAL-H, introduced by Noyori in 1979, is a chiral modifying reagent formed by combining lithium aluminum hydride (LiAlH₄) with equimolar (S)- or (R)-BINOL and ethanol. The …

2026-03-08
Methodology, Science 7 tags
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