BOX

5 articles

Copper-Catalyzed Asymmetric Conjugate Addition: Building Chiral Quaternary Centers

Copper-catalyzed asymmetric conjugate addition (ACA) is the method of choice for constructing chiral β-substituted carbonyls and all-carbon quaternary stereocenters. Organozinc, …

2026-06-05

Metal Catalysis, Science 7 tags

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Nickel-Catalyzed Asymmetric Cross-Coupling: Emerging Base-Metal Methodology

Nickel catalysis has emerged as one of the most active frontiers in asymmetric cross-coupling. Nickel’s ability to access both Ni(0)/Ni(II) and Ni(I)/Ni(III) redox cycles, …

2026-04-28

Metal Catalysis, Science 8 tags

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BOX Ligands in Lewis Acid Catalysis: t-Bu-BOX and Asymmetric Cycloadditions

Bisoxazoline (BOX) ligands, developed in the 1990s by Pfaltz, Ghosh, and Evans, are the dominant chiral scaffolds for Lewis acid-catalyzed asymmetric reactions. The …

2026-02-28

Methodology, Science 6 tags

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(R)-t-Bu-BOX

(R)-t-Bu-BOX is the enantiomeric form of (S)-t-Bu-BOX, providing complementary stereochemical control in copper- and zinc-catalyzed asymmetric transformations including …

0001-01-01

Chiral Ligands, Catalysts 4 tags

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(S)-t-Bu-BOX

(S)-t-Bu-BOX is a chiral C2-symmetric bisoxazoline (BOX) ligand featuring tert-butyl substituents that create a sterically demanding chiral pocket. It forms highly enantioselective …

0001-01-01

Chiral Ligands, Catalysts 4 tags

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