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rhodium asymmetric hydrogenation enamide dehydroamino acid DIPAMP BINAPINE SEGPHOS chiral ruthenium BINAP diamine aryl ketone DPEN DAIPEN Noyori asymmetric transfer hydrogenation TsDPEN ketone reduction palladium asymmetric cross-coupling Suzuki Heck atroposelective ketone CBS oxazaborolidine borane Corey copper conjugate addition 1,4-addition quaternary center phosphoramidite BOX chiral phosphoric acid TRIP BINOL organocatalysis Brønsted acid titanium TADDOL Lewis acid Diels-Alder carbonyl-ene cyanation metathesis Grubbs Hoveyda-Grubbs ring-closing cross-metathesis manganese Mn-salen Jacobsen base metal epoxidation pincer Buchwald biaryl phosphine SPhos XPhos RuPhos iridium unfunctionalized olefin MonoPhos Crabtree NHC IMes IPr carbene Trost DACH allylic alkylation API nickel Negishi spiro SPINOL SIPHOS Zhou Qi-Lin rigid backbone iron cobalt sustainable hydroformylation Xantphos Biphephos oxo process industrial C-H activation directing group olefin hydroboration hydrosilylation MacMillan imidazolidinone SOMO photoredox dual catalysis radical visible light cinchona alkaloid phase-transfer cinchonidine quinine Jorgensen Hayashi diarylprolinol enamine iminium BINAL-H chiral hydride reduction bisoxazoline cycloaddition t-Bu-BOX DIOP hydrogenation bisphosphine CHIRAPHOS PROPHOS evolution allylic substitution green chemistry flow chemistry ionic liquids proline DMAP sustainability process catalysis custom synthesis CDMO manufacturing

Spiro

5 articles

Taxonomy

Spiro Bisphosphine Ligands: SPINOL and SIPHOS in Asymmetric Catalysis

Chiral spiro ligands, developed primarily by Zhou Qi-Lin and coworkers at Nankai University, occupy a distinctive position in the ligand landscape. Their defining feature is a …

2026-04-22
Methodology, Science 6 tags
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Taxonomy

(R)-SIPHOS

(R)-SIPHOS is the enantiomeric form of (S)-SIPHOS, providing complementary stereochemistry in rhodium- and palladium-catalyzed asymmetric transformations based on the SPINOL …

0001-01-01
Chiral Ligands, Catalysts 5 tags
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Taxonomy

(R)-SPINOL

(R)-SPINOL is the enantiomeric form of (S)-SPINOL, providing complementary stereochemistry in the construction of SDP diphosphine and SIPHOS phosphoramidite ligands developed by …

0001-01-01
Chiral Ligands, Catalysts 5 tags
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Taxonomy

(S)-SIPHOS

(S)-SIPHOS is the chiral monodentate spiro phosphoramidite ligand developed by Zhou Qi-Lin. Built on the SPINOL scaffold, it forms highly enantioselective rhodium and palladium …

0001-01-01
Chiral Ligands, Catalysts 5 tags
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Taxonomy

(S)-SPINOL

(S)-SPINOL ((S)-1,1’-spirobiindane-7,7’-diol) is the privileged chiral spirocyclic diol developed by Zhou Qi-Lin. It serves as the core scaffold for SDP diphosphines, …

0001-01-01
Chiral Ligands, Catalysts 5 tags
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