BINOL

Metal Catalysis, Science 8 tags

Titanium-Catalyzed Asymmetric Lewis Acid Catalysis: TADDOLate and BINOLate Complexes

Titanium is the dominant Lewis acid metal for asymmetric catalysis, owing to its well-defined octahedral coordination geometry, tunable ligand sphere, and compatibility with a wide …

2026-05-26

Methodology, Science 7 tags

BINAL-H: Noyori's Chiral Hydride Reagent for Enantioselective Reduction

BINAL-H, introduced by Noyori in 1979, is a chiral modifying reagent formed by combining lithium aluminum hydride (LiAlH₄) with equimolar (S)- or (R)-BINOL and ethanol. The …

2026-03-08

Methodology, Science 7 tags

Phosphoramidite Ligands: MonoPhos and the Modular Approach to Asymmetric Catalysis

Phosphoramidite ligands, introduced by Feringa and de Vries in the late 1990s, are a modular class of monodentate chiral phosphorus ligands derived from BINOL and secondary amines. …

2026-02-05

(R)-BINAL-H

(R)-BINAL-H is the enantiomeric chiral reducing agent of (S)-BINAL-H, prepared from (R)-BINOL. It provides access to opposite enantiomers in the asymmetric reduction of aromatic …

(R)-BINOL

(R)-BINOL is the enantiomeric form of (S)-BINOL, providing the mirror-image chiral environment required for opposite enantioselectivity in metal-catalyzed and organocatalytic …

Chiral Ligands, Catalysts 4 tags

(R)-TRIP BINOL Phosphoric Acid

(R)-TRIP is the enantiomeric chiral phosphoric acid catalyst that provides access to opposite enantiomers in asymmetric Brønsted acid catalysis. It is the catalyst of choice for …

(S)-BINAL-H

(S)-BINAL-H is the chiral aluminum hydride reducing agent developed by Noyori, prepared from (S)-BINOL, lithium aluminum hydride, and an alcohol. It is renowned for asymmetric …

(S)-BINOL

(S)-BINOL is one of the most versatile chiral ligands in asymmetric catalysis, serving as the precursor for chiral phosphoric acids, BINAP, BINAL-H, and numerous metal complexes. …

Chiral Ligands, Catalysts 4 tags

(S)-MonoPhos

(S)-MonoPhos is a chiral monodentate phosphoramidite ligand developed by Feringa and de Vries. Derived from (S)-BINOL, it forms highly enantioselective rhodium complexes for …

Chiral Ligands, Catalysts 5 tags

(S)-TRIP BINOL Phosphoric Acid

(S)-TRIP is the most widely used chiral phosphoric acid catalyst developed by List and Akiyama, enabling highly enantioselective transformations of imines, indoles, and other …