NHC-Catalyzed Organic Transformations with IMes and IPr Precatalysts
N-heterocyclic carbenes (NHCs) have, since the late 1990s, become indispensable ligands in transition-metal catalysis. The two most widely used NHCs — IMes …
5 articles
N-heterocyclic carbenes (NHCs) have, since the late 1990s, become indispensable ligands in transition-metal catalysis. The two most widely used NHCs — IMes …
Grubbs 2nd generation catalyst is the iconic ruthenium-NHC complex developed by Robert Grubbs for olefin metathesis. It offers superior activity, thermal stability, and functional …
Hoveyda-Grubbs 2nd generation catalyst is a chelated ruthenium-NHC complex developed by Hoveyda. Its “boomerang” mechanism allows catalyst recovery and recycling, …
IMes·HCl (1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride) is the foundational N-heterocyclic carbene (NHC) precatalyst developed by Arduengo. Deprotonation generates the IMes …
IPr·HCl (1,3-bis(2,6-diisopropylphenyl)imidazolium chloride) is the most widely deployed NHC precatalyst in modern transition-metal catalysis. The sterically demanding IPr carbene …