Cross-Coupling

Taxonomy

Palladium-Catalyzed Enantioselective Cross-Coupling: Atroposelective Suzuki and Asymmetric Heck

While most palladium cross-coupling uses achiral phosphines, a growing family of enantioselective Pd-catalyzed reactions uses chiral diphosphines to construct stereocenters and …

2026-06-12

Metal Catalysis, Science 8 tags

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Buchwald Biaryl Phosphine Ligands: Revolutionizing Palladium-Catalyzed Cross-Coupling

Palladium-catalyzed cross-coupling has been transformed over the past two decades by Stephen Buchwald’s development of electron-rich, sterically demanding biaryl phosphine …

2026-05-15

Methodology, Science 7 tags

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NHC-Catalyzed Organic Transformations with IMes and IPr Precatalysts

N-heterocyclic carbenes (NHCs) have, since the late 1990s, become indispensable ligands in transition-metal catalysis. The two most widely used NHCs — IMes …

2026-05-08

Methodology, Science 7 tags

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Nickel-Catalyzed Asymmetric Cross-Coupling: Emerging Base-Metal Methodology

Nickel catalysis has emerged as one of the most active frontiers in asymmetric cross-coupling. Nickel’s ability to access both Ni(0)/Ni(II) and Ni(I)/Ni(III) redox cycles, …

2026-04-28

Metal Catalysis, Science 8 tags

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IMes·HCl

IMes·HCl (1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride) is the foundational N-heterocyclic carbene (NHC) precatalyst developed by Arduengo. Deprotonation generates the IMes …

0001-01-01

Catalyst Precursors, Catalysts 5 tags

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IPr·HCl

IPr·HCl (1,3-bis(2,6-diisopropylphenyl)imidazolium chloride) is the most widely deployed NHC precatalyst in modern transition-metal catalysis. The sterically demanding IPr carbene …

0001-01-01

Catalyst Precursors, Catalysts 5 tags

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RuPhos

RuPhos (2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1’-biphenyl) is a Buchwald biaryl phosphine ligand optimized for C–N cross-coupling. It excels at coupling …

0001-01-01

Catalyst Ligands, Catalysts 4 tags

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SPhos

SPhos (2-dicyclohexylphosphino-2’,6’-dimethoxybiphenyl) is the iconic Buchwald biaryl phosphine ligand. Its electron-rich and sterically demanding character enables …

0001-01-01

Catalyst Ligands, Catalysts 4 tags

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Xantphos

Xantphos (4,5-bis(diphenylphosphino)-9,9-dimethylxanthene) is the privileged wide bite-angle (≈108°) bidentate phosphine ligand developed by van Leeuwen. It is the industry …

0001-01-01

Catalyst Ligands, Catalysts 4 tags

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XPhos

XPhos (2-dicyclohexylphosphino-2’,4’,6’-triisopropylbiphenyl) is a privileged Buchwald biaryl phosphine ligand. The bulky, electron-rich character enables highly …

0001-01-01

Catalyst Ligands, Catalysts 4 tags

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