Asymmetric Hydrogenation

Taxonomy

Rhodium-Catalyzed Asymmetric Hydrogenation of Enamides and Dehydroamino Acids

Rhodium-catalyzed asymmetric hydrogenation is the most mature and industrially deployed of all enantioselective metal-catalyzed transformations. The cationic …

2026-06-25

Metal Catalysis, Science 8 tags

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Ruthenium (BINAP)(Diamine) Catalysts for Asymmetric Hydrogenation of Aryl Ketones

While first-generation (BINAP)RuCl₂ catalysts excel at β-keto esters, they give poor enantioselectivity on unfunctionalized aryl ketones. Noyori’s breakthrough was the …

2026-06-20

Metal Catalysis, Science 9 tags

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BINAP–Ruthenium Catalyzed Asymmetric Hydrogenation: Noyori's Foundational Platform

The combination of (BINAP)RuCl₂ with a chiral 1,2-diamine co-ligand, recognized by the 2001 Nobel Prize awarded to Ryoji Noyori, established the modern field of asymmetric …

2026-06-10

Methodology, Science 6 tags

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Iridium-Catalyzed Asymmetric Hydrogenation of Unfunctionalized Olefins

Rhodium and ruthenium catalysts dominate asymmetric hydrogenation of functionalized olefins (enamides, enol esters), but they frequently fail on unfunctionalized, tri-substituted, …

2026-05-10

Metal Catalysis, Science 7 tags

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Iron and Cobalt Base-Metal Asymmetric Catalysis: Sustainable Alternatives to Precious Metals

The drive to replace scarce, expensive precious metals (Ru, Rh, Ir, Pd) with earth-abundant base metals (Fe, Co, Mn, Ni, Cu) is reshaping asymmetric catalysis. Iron and cobalt, the …

2026-04-20

Metal Catalysis, Science 7 tags

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Taxonomy

(R)-BINAP-Ru(II) Dichloride

(R)-BINAP-Ru(II) dichloride is the enantiomeric counterpart of (S)-BINAP-Ru(II) dichloride, providing access to the opposite enantiomer in asymmetric hydrogenation reactions. It is …

0001-01-01

Chiral Catalysts, Catalysts 4 tags

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(R)-DIPAMP

(R)-DIPAMP is the enantiomeric P-stereogenic bidentate phosphine ligand, providing access to opposite enantiomers in rhodium-catalyzed asymmetric hydrogenation of dehydroamino …

0001-01-01

Chiral Ligands, Catalysts 4 tags

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(S)-BINAP-Ru(II) Dichloride

(S)-BINAP-Ru(II) dichloride is a privileged chiral ruthenium catalyst developed by Noyori and coworkers, renowned for enabling highly enantioselective hydrogenation of …

0001-01-01

Chiral Catalysts, Catalysts 4 tags

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(S)-DIPAMP

(S)-DIPAMP is the chiral bidentate phosphine ligand used by William Knowles in the landmark industrial synthesis of L-DOPA, the achievement recognized with the 2001 Nobel Prize in …

0001-01-01

Chiral Ligands, Catalysts 4 tags

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[(S)-DIOP]RhCl Dimer

[(S)-DIOP]RhCl dimer is the chiral rhodium complex of DIOP, the first practical chiral bidentate phosphine ligand developed by Kagan. It catalyzes asymmetric hydrogenation of …

0001-01-01

Chiral Catalysts, Catalysts 4 tags

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