Organocatalysis

Taxonomy

Chiral Phosphoric Acid Catalysis with TRIP-BINOL: Organocatalytic Asymmetric Activation

Chiral phosphoric acids (CPAs) derived from 3,3’-disubstituted BINOL have, since the seminal work of Akiyama and Terada around 2004, grown into one of the most versatile …

2026-05-28

Methodology, Science 6 tags

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Taxonomy

MacMillan Imidazolidinone Organocatalysts: SOMO Catalysis and Asymmetric Diels–Alder

David MacMillan’s imidazolidinone organocatalysts, introduced in 2000, established iminium activation as a complementary strategy to enamine catalysis. The catalysts condense …

2026-03-30

Methodology, Science 6 tags

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Taxonomy

Cinchona Alkaloids in Asymmetric Organocatalysis and Phase-Transfer Catalysis

Cinchona alkaloids — cinchonidine, cinchonine, quinine, and quinidine — are among the oldest chiral catalysts in organic chemistry. Extracted from the bark of Cinchona trees, these …

2026-03-22

Methodology, Science 7 tags

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Taxonomy

Jørgensen–Hayashi Diarylprolinol Silyl Ethers in Enamine and Iminium Catalysis

The Jørgensen–Hayashi catalyst — a chiral diphenylprolinol silyl ether — emerged around 2005 as a solution to the long-standing problem of enantioselective α-functionalization of …

2026-03-15

Methodology, Science 7 tags

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Taxonomy

(R)-TRIP BINOL Phosphoric Acid

(R)-TRIP is the enantiomeric chiral phosphoric acid catalyst that provides access to opposite enantiomers in asymmetric Brønsted acid catalysis. It is the catalyst of choice for …

0001-01-01

Chiral Catalysts, Catalysts 4 tags

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Taxonomy

(S)-TRIP BINOL Phosphoric Acid

(S)-TRIP is the most widely used chiral phosphoric acid catalyst developed by List and Akiyama, enabling highly enantioselective transformations of imines, indoles, and other …

0001-01-01

Chiral Catalysts, Catalysts 4 tags

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