Noyori

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Ruthenium (BINAP)(Diamine) Catalysts for Asymmetric Hydrogenation of Aryl Ketones

While first-generation (BINAP)RuCl₂ catalysts excel at β-keto esters, they give poor enantioselectivity on unfunctionalized aryl ketones. Noyori’s breakthrough was the …

2026-06-20

Metal Catalysis, Science 9 tags

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Asymmetric Transfer Hydrogenation with Noyori–Ikariya Ru-TsDPEN Catalysts

Asymmetric transfer hydrogenation (ATH) is one of the most operationally simple methods for reducing prochiral ketones and imines to chiral alcohols and amines. Developed by Noyori …

2026-06-15

Methodology, Science 6 tags

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BINAP–Ruthenium Catalyzed Asymmetric Hydrogenation: Noyori's Foundational Platform

The combination of (BINAP)RuCl₂ with a chiral 1,2-diamine co-ligand, recognized by the 2001 Nobel Prize awarded to Ryoji Noyori, established the modern field of asymmetric …

2026-06-10

Methodology, Science 6 tags

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BINAL-H: Noyori's Chiral Hydride Reagent for Enantioselective Reduction

BINAL-H, introduced by Noyori in 1979, is a chiral modifying reagent formed by combining lithium aluminum hydride (LiAlH₄) with equimolar (S)- or (R)-BINOL and ethanol. The …

2026-03-08

Methodology, Science 7 tags

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(R,R)-TsDPEN

(R,R)-TsDPEN is the enantiomeric form of (S,S)-TsDPEN, providing complementary stereochemical outcomes in ruthenium-catalyzed asymmetric transfer hydrogenation of prochiral ketones …

0001-01-01

Chiral Catalysts, Catalysts 5 tags

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(S,S)-TsDPEN

(S,S)-TsDPEN (N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine) is the privileged chiral diamine ligand developed by Noyori and Ikariya. Combined with η⁶-arene-Ru(II) precursors, …

0001-01-01

Chiral Catalysts, Catalysts 5 tags

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